Tonawanda News — That changed over the past two days when Manuel’s knee did not respond to treatment.
Though Manuel won’t play this weekend, Marrone said he felt “very confident” that Manuel will start in the Bills finale at New England on Dec. 29.
The injury comes after Manuel had won his first road game of the season, and had a chance to help Buffalo string together consecutive wins for the first time since Weeks 2 and 3 of 2012.
Manuel is 3-2 at home and has struggled with his consistency on the road.
Lewis has proven to be a capable backup since being promoted from the practice squad on Oct. 7. He went 1-2 in place of Manuel earlier this season before Lewis was sidelined by a rib injury in a 35-17 loss at New Orleans.
Lewis’ victory came against the Dolphins on Oct. 20, when he went 21 of 32 for 202 yards and an interception in the 23-21 win.
The Bills acquired Lewis in a trade with Detroit in August, after Manuel hurt his left knee.
He was cut by Buffalo before the start of the season and then signed to the team’s practice squad.
Overall, the Duke product has gone 62 of 103 for 652 yards with three touchdowns and two interceptions.
Receiver Stevie Johnson is also not expected to play, Marrone said. Johnson has been excused to be with his family in California following the unexpected death of the player’s mother on Saturday.
“I don’t believe that he will be available for our game on Sunday,” Marrone said. “And I think it’s important we realize this tragedy, and our thoughts and prayers are with Stevie and his family.”
Marrone also considered starting safety Aaron Williams’ chances of playing on Sunday as “50-50.” Williams did not practice after hurting his ribs while making a tackle in the fourth quarter against Jacksonville.